Functional Analysis of the Disulfide-Bonded Loop/Chain Reversal Region of Human Immunodeficiency Virus Type 1 gp41 Reveals a Critical Role in gp120-gp41 Association

Human immunodeficiency virus type 1 (HIV-1) entry into cells is mediated by the surface-exposed envelope protein (SU) gp120, which binds to cellular CD4 and chemokine receptors, triggering the membrane fusion activity of the transmembrane (TM) protein gp41. The core of gp41 comprises an N-terminal t...

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Detalhes bibliográficos
Main Authors: Maerz, Anne L., Drummer, Heidi E., Wilson, Kirilee A., Poumbourios, Pantelis
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Structure and Assembly
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC114387/
https://ncbi.nlm.nih.gov/pubmed/11413331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.14.6635-6644.2001
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