Insertion of an Imprinted Insulator into the IgH Locus Reveals Developmentally Regulated, Transcription-Dependent Control of V(D)J Recombination

The assembly of antigen receptor loci requires a developmentally regulated and lineage-specific recombination between variable (V), diversity (D), and joining (J) segments through V(D)J recombination. The process is regulated by accessibility control elements, including promoters, insulators, and en...

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Publicat a:Mol Cell Biol
Autors principals: Puget, Nadine, Hirasawa, Ryutaro, Hu, Ngoc-Sa Nguyen, Laviolette-Malirat, Nathalie, Feil, Robert, Khamlichi, Ahmed Amine
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2015
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4285425/
https://ncbi.nlm.nih.gov/pubmed/25403489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00235-14
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