Sense transcription through the S region is essential for immunoglobulin class switch recombination

Class switch recombination (CSR) occurs between highly repetitive sequences called switch (S) regions and is initiated by activation-induced cytidine deaminase (AID). CSR is preceded by a bidirectional transcription of S regions but the relative importance of sense and antisense transcription for CS...

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Main Authors: Haddad, Dania, Oruc, Zéliha, Puget, Nadine, Laviolette-Malirat, Nathalie, Philippe, Magali, Carrion, Claire, Le Bert, Marc, Khamlichi, Ahmed Amine
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3102270/
https://ncbi.nlm.nih.gov/pubmed/21378751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.56
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