Structural basis of HIV-1 capsid recognition by PF74 and CPSF6

Upon infection of susceptible cells by HIV-1, the conical capsid formed by ∼250 hexamers and 12 pentamers of the CA protein is delivered to the cytoplasm. The capsid shields the RNA genome and proteins required for reverse transcription. In addition, the surface of the capsid mediates numerous host–...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Bhattacharya, Akash, Alam, Steven L., Fricke, Thomas, Zadrozny, Kaneil, Sedzicki, Jaroslaw, Taylor, Alexander B., Demeler, Borries, Pornillos, Owen, Ganser-Pornillos, Barbie K., Diaz-Griffero, Felipe, Ivanov, Dmitri N., Yeager, Mark
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2014
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4284599/
https://ncbi.nlm.nih.gov/pubmed/25518861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1419945112
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