Kinetic Mechanisms Governing Stable Ribonucleotide Incorporation in Individual DNA Polymerase Complexes

[Image: see text] Ribonucleoside triphosphates (rNTPs) are frequently incorporated during DNA synthesis by replicative DNA polymerases (DNAPs), and once incorporated are not efficiently edited by the DNAP exonucleolytic function. We examined the kinetic mechanisms that govern selection of complement...

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Publicado en:Biochemistry
Autores principales: Dahl, Joseph M., Wang, Hongyun, Lázaro, José M., Salas, Margarita, Lieberman, Kate R.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2014
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4283934/
https://ncbi.nlm.nih.gov/pubmed/25478721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi501216a
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