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Kinetic Mechanisms Governing Stable Ribonucleotide Incorporation in Individual DNA Polymerase Complexes

[Image: see text] Ribonucleoside triphosphates (rNTPs) are frequently incorporated during DNA synthesis by replicative DNA polymerases (DNAPs), and once incorporated are not efficiently edited by the DNAP exonucleolytic function. We examined the kinetic mechanisms that govern selection of complement...

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Publicat a:Biochemistry
Autors principals: Dahl, Joseph M., Wang, Hongyun, Lázaro, José M., Salas, Margarita, Lieberman, Kate R.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2014
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4283934/
https://ncbi.nlm.nih.gov/pubmed/25478721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi501216a
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