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Kinetic Mechanisms Governing Stable Ribonucleotide Incorporation in Individual DNA Polymerase Complexes

[Image: see text] Ribonucleoside triphosphates (rNTPs) are frequently incorporated during DNA synthesis by replicative DNA polymerases (DNAPs), and once incorporated are not efficiently edited by the DNAP exonucleolytic function. We examined the kinetic mechanisms that govern selection of complement...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Dahl, Joseph M., Wang, Hongyun, Lázaro, José M., Salas, Margarita, Lieberman, Kate R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4283934/
https://ncbi.nlm.nih.gov/pubmed/25478721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi501216a
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