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Kinetic Mechanism of Translocation and dNTP Binding in Individual DNA Polymerase Complexes

Complexes formed between phi29 DNA polymerase (DNAP) and DNA fluctuate discretely between the pre-translocation and post-translocation states on the millisecond time scale. The translocation fluctuations can be observed in ionic current traces when individual complexes are captured atop the α-hemoly...

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Hlavní autoři: Lieberman, Kate R., Dahl, Joseph M., Mai, Ai H., Cox, Ashley, Akeson, Mark, Wang, Hongyun
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3738007/
https://ncbi.nlm.nih.gov/pubmed/23705688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja403640b
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