A preclinical orthotopic model for glioblastoma recapitulates key features of human tumors and demonstrates sensitivity to a combination of MEK and PI3K pathway inhibitors

Current therapies for glioblastoma multiforme (GBM), the highest grade malignant brain tumor, are mostly ineffective, and better preclinical model systems are needed to increase the successful translation of drug discovery efforts into the clinic. Previous work describes a genetically engineered mou...

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Vydáno v:Dis Model Mech
Hlavní autoři: El Meskini, Rajaa, Iacovelli, Anthony J., Kulaga, Alan, Gumprecht, Michelle, Martin, Philip L., Baran, Maureen, Householder, Deborah B., Van Dyke, Terry, Weaver Ohler, Zoë
Médium: Artigo
Jazyk:Inglês
Vydáno: The Company of Biologists Limited 2015
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4283649/
https://ncbi.nlm.nih.gov/pubmed/25431423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.018168
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