A preclinical orthotopic model for glioblastoma recapitulates key features of human tumors and demonstrates sensitivity to a combination of MEK and PI3K pathway inhibitors

Por El Meskini, Rajaa, Iacovelli, Anthony J., Kulaga, Alan, Gumprecht, Michelle, Martin, Philip L., Baran, Maureen, Householder, Deborah B., Van Dyke, Terry, Weaver Ohler, Zoë
Publicado no Dis Model Mech (2015)

Synergistic targeted inhibition of MEK and dual PI3K/mTOR diminishes viability and inhibits tumor growth of canine melanoma underscoring its utility as a preclinical model for huma...

Por Wei, Bih‐Rong, Michael, Helen T., Halsey, Charles H.C., Peer, Cody J., Adhikari, Amit, Dwyer, Jennifer E., Hoover, Shelley B., El Meskini, Rajaa, Kozlov, Serguei, Weaver Ohler, Zoe, Figg, William. D., Merlino, Glenn, Simpson, R. Mark
Publicado no Pigment Cell Melanoma Res (2016)