A preclinical orthotopic model for glioblastoma recapitulates key features of human tumors and demonstrates sensitivity to a combination of MEK and PI3K pathway inhibitors

Current therapies for glioblastoma multiforme (GBM), the highest grade malignant brain tumor, are mostly ineffective, and better preclinical model systems are needed to increase the successful translation of drug discovery efforts into the clinic. Previous work describes a genetically engineered mou...

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Detalhes bibliográficos
Publicado no:Dis Model Mech
Main Authors: El Meskini, Rajaa, Iacovelli, Anthony J., Kulaga, Alan, Gumprecht, Michelle, Martin, Philip L., Baran, Maureen, Householder, Deborah B., Van Dyke, Terry, Weaver Ohler, Zoë
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Limited 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4283649/
https://ncbi.nlm.nih.gov/pubmed/25431423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.018168
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