Synergistic Effects of Concurrent Blockade of PI3K and MEK Pathways in Pancreatic Cancer Preclinical Models

Patients with pancreatic cancer have dismal prognoses, and novel therapies are urgently needed. Mutations of the KRAS oncogene occur frequently in pancreatic cancer and represent an attractive target. Direct targeting of the predominant KRAS pathways have been challenging and research into therapeut...

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Detalhes bibliográficos
Main Authors: Zhong, Hua, Sanchez, Cesar, Spitrzer, Dirk, Plambeck-Suess, Stacy, Gibbs, Jesse, Hawkins, Williams G., Denardo, David, Gao, Feng, Pufahl, Robert A., Lockhart, Albert C., Xu, Mai, Linehan, David, Weber, Jason, Wang-Gillam, Andrea
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3793961/
https://ncbi.nlm.nih.gov/pubmed/24130864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0077243
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