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Specification of Vδ and Vα usage by Tcra/Tcrd locus V gene segment promoters,2

The Tcra/Tcrd locus undergoes V-Dδ-Jδ rearrangement in CD4(−)CD8(−) thymocytes to form the TCRδ chain of the γδ TCR and V-Jα rearrangement in CD4(+)CD8(+) thymocytes to form the TCRα chain of the αβ TCR. Most V segments in the locus participate in V-Jα rearrangement, but only a small and partially o...

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Bibliografske podrobnosti
izdano v:J Immunol
Main Authors: Naik, Abani K., Hawwari, Abbas, Krangel, Michael S.
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4282949/
https://ncbi.nlm.nih.gov/pubmed/25472997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1402423
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