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Arhgef7 promotes activation of the Hippo pathway core kinase Lats
The Hippo pathway regulates tissue growth and organ size, and inactivation contributes to cancer. Signals flow through Mst/Lats kinases, which phosphorylate and promote cytoplasmic localization of the transcriptional regulators Yap and Taz to inhibit transcription. Here, we identify the multidomain-...
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| Published in: | EMBO J |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Blackwell Publishing Ltd
2014
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4282645/ https://ncbi.nlm.nih.gov/pubmed/25425573 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201490230 |
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