Deubiquitinating Enzyme USP9X Suppresses Tumor Growth via LATS kinase and Core Components of the Hippo pathway

The core LATS kinases of the Hippo tumor suppressor pathway phosphorylate and inhibit the downstream transcriptional co-activators YAP and TAZ, which are implicated in various cancers. Recent studies have identified various E3 ubiquitin ligases that negatively regulate the Hippo pathway via ubiquiti...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Toloczko, Aleksandra, Guo, Fusheng, Yuen, Hiu-Fung, Wen, Qing, Wood, Stephen A., Ong, Yan Shan, Chan, Pei Yi, Shaik, Asfa Alli, Gunaratne, Jayantha, Dunne, Mark J., Hong, Wanjin, Chan, Siew Wee
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6047736/
https://ncbi.nlm.nih.gov/pubmed/28720576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-3413
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