Deubiquitinating Enzyme USP9X Suppresses Tumor Growth via LATS kinase and Core Components of the Hippo pathway

The core LATS kinases of the Hippo tumor suppressor pathway phosphorylate and inhibit the downstream transcriptional co-activators YAP and TAZ, which are implicated in various cancers. Recent studies have identified various E3 ubiquitin ligases that negatively regulate the Hippo pathway via ubiquiti...

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Gepubliceerd in:Cancer Res
Hoofdauteurs: Toloczko, Aleksandra, Guo, Fusheng, Yuen, Hiu-Fung, Wen, Qing, Wood, Stephen A., Ong, Yan Shan, Chan, Pei Yi, Shaik, Asfa Alli, Gunaratne, Jayantha, Dunne, Mark J., Hong, Wanjin, Chan, Siew Wee
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6047736/
https://ncbi.nlm.nih.gov/pubmed/28720576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-3413
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