IκΒα inhibits apoptosis at the outer mitochondrial membrane independently of NF-κB retention

IκBα resides in the cytosol where it retains the inducible transcription factor NF-κB. We show that IκBα also localises to the outer mitochondrial membrane (OMM) to inhibit apoptosis. This effect is especially pronounced in tumour cells with constitutively active NF-κB that accumulate high amounts o...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:EMBO J
Hlavní autoři: Pazarentzos, Evangelos, Mahul-Mellier, Anne-Laure, Datler, Christoph, Chaisaklert, Wanwisa, Hwang, Ming-Shih, Kroon, Jan, Qize, Ding, Osborne, Foy, Al-Rubaish, Abdullah, Al-Ali, Amein, Mazarakis, Nicholas D, Aboagye, Eric O, Grimm, Stefan
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Publishing Ltd 2014
Témata:
Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4282558/
https://ncbi.nlm.nih.gov/pubmed/25361605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201488183
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky