IκΒα inhibits apoptosis at the outer mitochondrial membrane independently of NF-κB retention

IκBα resides in the cytosol where it retains the inducible transcription factor NF-κB. We show that IκBα also localises to the outer mitochondrial membrane (OMM) to inhibit apoptosis. This effect is especially pronounced in tumour cells with constitutively active NF-κB that accumulate high amounts o...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Pazarentzos, Evangelos, Mahul-Mellier, Anne-Laure, Datler, Christoph, Chaisaklert, Wanwisa, Hwang, Ming-Shih, Kroon, Jan, Qize, Ding, Osborne, Foy, Al-Rubaish, Abdullah, Al-Ali, Amein, Mazarakis, Nicholas D, Aboagye, Eric O, Grimm, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4282558/
https://ncbi.nlm.nih.gov/pubmed/25361605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201488183
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