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De-ubiquitinating protease USP2a targets RIP1 and TRAF2 to mediate cell death by TNF
Components of the TNFR1 complex are subject to dynamic ubiquitination that impacts on their effects as signalling factors. We have found that the ubiquitin-specific protease USP2a has a pivotal role in the decision for cell death or survival by the TNFR1 complex. This enzyme is a novel component of...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3321630/ https://ncbi.nlm.nih.gov/pubmed/22179575 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2011.185 |
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