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The anticancer gene ORCTL3 targets stearoyl-CoA desaturase-1 for tumour-specific apoptosis

ORCTL3 is a member of a group of genes, the so-called anticancer genes, that cause tumour-specific cell death. We show that this activity is triggered in isogenic renal cells upon their transformation independently of the cells’ proliferation status. For its cell death effect ORCTL3 targets the enzy...

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Autors principals: AbuAli, G, Chaisaklert, W, Stelloo, E, Pazarentzos, E, Hwang, M-S, Qize, D, Harding, SV, Al-Rubaish, A, Alzahrani, A-H, Al-Ali, A, Sanders, TAB, Aboagye, E O, Grimm, S
Format: Artigo
Idioma:Inglês
Publicat: 2014
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4119473/
https://ncbi.nlm.nih.gov/pubmed/24769897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.93
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