Discovery of Tumor-Specific Irreversible Inhibitors of Stearoyl CoA Desaturase

A hallmark of targeted cancer therapies is selective toxicity among cancer cell lines. We evaluated results from a viability screen of over 200,000 small molecules to identify two chemical series, oxalamides and benzothiazoles, that were selectively toxic to the same four of 12 human lung cancer cel...

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Detalhes bibliográficos
Publicado no:Nat Chem Biol
Main Authors: Theodoropoulos, Panayotis C., Gonzales, Stephen S., Winterton, Sarah E., Rodriguez-Navas, Carlos, McKnight, John S., Morlock, Lorraine K., Hanson, Jordan M., Cross, Bethany, Owen, Amy E., Duan, Yingli, Moreno, Jose R., Lemoff, Andrew, Mirzaei, Hamid, Posner, Bruce A., Williams, Noelle S., Ready, Joseph M., Nijhawan, Deepak
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4798879/
https://ncbi.nlm.nih.gov/pubmed/26829472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2016
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