Discovery of Tumor-Specific Irreversible Inhibitors of Stearoyl CoA Desaturase

A hallmark of targeted cancer therapies is selective toxicity among cancer cell lines. We evaluated results from a viability screen of over 200,000 small molecules to identify two chemical series, oxalamides and benzothiazoles, that were selectively toxic to the same four of 12 human lung cancer cel...

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Vydáno v:Nat Chem Biol
Hlavní autoři: Theodoropoulos, Panayotis C., Gonzales, Stephen S., Winterton, Sarah E., Rodriguez-Navas, Carlos, McKnight, John S., Morlock, Lorraine K., Hanson, Jordan M., Cross, Bethany, Owen, Amy E., Duan, Yingli, Moreno, Jose R., Lemoff, Andrew, Mirzaei, Hamid, Posner, Bruce A., Williams, Noelle S., Ready, Joseph M., Nijhawan, Deepak
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4798879/
https://ncbi.nlm.nih.gov/pubmed/26829472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2016
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