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Discovery of Cytochrome P450 4F11 Activated Inhibitors of Stearoyl Coenzyme A Desaturase

Stearoyl-CoA desaturase (SCD) catalyzes the first step in the conversion of saturated fatty acids to unsaturated fatty acids. Unsaturated fatty acids are required for membrane integrity and for cell proliferation. For these reasons, inhibitors of SCD represent potential treatments for cancer. Howeve...

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Библиографические подробности
Опубликовано в: :J Med Chem
Главные авторы: Winterton, Sarah E., Capota, Emanuela, Wang, Xiaoyu, Chen, Hong, Mallipeddi, Prema L., Williams, Noelle S., Posner, Bruce A., Nijhawan, Deepak, Ready, Joseph M.
Формат: Artigo
Язык:Inglês
Опубликовано: 2018
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6350083/
https://ncbi.nlm.nih.gov/pubmed/29869888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b00052
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