BID-dependent release of mitochondrial SMAC dampens XIAP-mediated immunity against Shigella

The X-linked inhibitor of apoptosis protein (XIAP) is a potent caspase inhibitor, best known for its anti-apoptotic function in cancer. During apoptosis, XIAP is antagonized by SMAC, which is released from the mitochondria upon caspase-mediated activation of BID. Recent studies suggest that XIAP is...

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Publicado no:EMBO J
Main Authors: Andree, Maria, Seeger, Jens M, Schüll, Stephan, Coutelle, Oliver, Wagner-Stippich, Diana, Wiegmann, Katja, Wunderlich, Claudia M, Brinkmann, Kerstin, Broxtermann, Pia, Witt, Axel, Fritsch, Melanie, Martinelli, Paola, Bielig, Harald, Lamkemeyer, Tobias, Rugarli, Elena I, Kaufmann, Thomas, Sterner-Kock, Anja, Wunderlich, F Thomas, Villunger, Andreas, Martins, L Miguel, Krönke, Martin, Kufer, Thomas A, Utermöhlen, Olaf, Kashkar, Hamid
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4282505/
https://ncbi.nlm.nih.gov/pubmed/25056906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201387244
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