XIAP impairs Smac release from the mitochondria during apoptosis

X-linked inhibitor of apoptosis protein (XIAP) is a potent inhibitor of caspases 3, 7 and 9, and mitochondrial Smac (second mitochondria-derived activator of caspase) release during apoptosis inhibits the activity of XIAP. In this study we show that cytosolic XIAP also feeds back to mitochondria to...

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Bibliografiske detaljer
Main Authors:	Flanagan, L, Sebastià, J, Tuffy, L P, Spring, A, Lichawska, A, Devocelle, M, Prehn, J H M, Rehm, M
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Publishing Group 2010
Fag:	Original Article
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3032314/ https://ncbi.nlm.nih.gov/pubmed/21364655 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2010.26
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XIAP impairs Smac release from the mitochondria during apoptosis

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