Determinants of G quadruplex-induced epigenetic instability in REV1-deficient cells

REV1-deficient chicken DT40 cells are compromised in replicating G quadruplex (G4)-forming DNA. This results in localised, stochastic loss of parental chromatin marks and changes in gene expression. We previously proposed that this epigenetic instability arises from G4-induced replication fork stall...

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Vydáno v:EMBO J
Hlavní autoři: Schiavone, Davide, Guilbaud, Guillaume, Murat, Pierre, Papadopoulou, Charikleia, Sarkies, Peter, Prioleau, Marie-Noëlle, Balasubramanian, Shankar, Sale, Julian E
Médium: Artigo
Jazyk:Inglês
Vydáno: BlackWell Publishing Ltd 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4282387/
https://ncbi.nlm.nih.gov/pubmed/25190518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201488398
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