PrimPol Is Required for Replicative Tolerance of G Quadruplexes in Vertebrate Cells

G quadruplexes (G4s) can present potent blocks to DNA replication. Accurate and timely replication of G4s in vertebrates requires multiple specialized DNA helicases and polymerases to prevent genetic and epigenetic instability. Here we report that PrimPol, a recently described primase-polymerase (Pr...

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Bibliografiska uppgifter
I publikationen:Mol Cell
Huvudupphovsmän: Schiavone, Davide, Jozwiakowski, Stanislaw K., Romanello, Marina, Guilbaud, Guillaume, Guilliam, Thomas A., Bailey, Laura J., Sale, Julian E., Doherty, Aidan J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Cell Press 2016
Ämnen:
Short Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4712188/
https://ncbi.nlm.nih.gov/pubmed/26626482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.10.038
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