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PrimPol Is Required for Replicative Tolerance of G Quadruplexes in Vertebrate Cells
G quadruplexes (G4s) can present potent blocks to DNA replication. Accurate and timely replication of G4s in vertebrates requires multiple specialized DNA helicases and polymerases to prevent genetic and epigenetic instability. Here we report that PrimPol, a recently described primase-polymerase (Pr...
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| Publicado no: | Mol Cell |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cell Press
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4712188/ https://ncbi.nlm.nih.gov/pubmed/26626482 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.10.038 |
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