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Human PrimPol mutation associated with high myopia has a DNA replication defect

PrimPol is a primase-polymerase found in humans, and other eukaryotes, involved in bypassing lesions encountered during DNA replication. PrimPol employs both translesion synthesis and repriming mechanisms to facilitate lesion bypass by the replisome. PrimPol has been reported to be a potential susce...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Keen, Benjamin A., Bailey, Laura J., Jozwiakowski, Stanislaw K., Doherty, Aidan J.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4231748/
https://ncbi.nlm.nih.gov/pubmed/25262353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku879
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