Human PrimPol is a highly error-prone polymerase regulated by single-stranded DNA binding proteins

PrimPol is a recently identified polymerase involved in eukaryotic DNA damage tolerance, employed in both re-priming and translesion synthesis mechanisms to bypass nuclear and mitochondrial DNA lesions. In this report, we investigate how the enzymatic activities of human PrimPol are regulated. We sh...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Guilliam, Thomas A., Jozwiakowski, Stanislaw K., Ehlinger, Aaron, Barnes, Ryan P., Rudd, Sean G., Bailey, Laura J., Skehel, J. Mark, Eckert, Kristin A., Chazin, Walter J., Doherty, Aidan J.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2015
Subjects:
Nucleic Acid Enzymes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4333378/
https://ncbi.nlm.nih.gov/pubmed/25550423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku1321
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