FANCJ coordinates two pathways that maintain epigenetic stability at G-quadruplex DNA

We have previously reported that DT40 cells deficient in the Y-family polymerase REV1 are defective in replicating G-quadruplex DNA. In vivo this leads to uncoupling of DNA synthesis from redeposition of histones displaced ahead of the replication fork, which in turn leads to loss of transcriptional...

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Bibliographic Details
Main Authors: Sarkies, Peter, Murat, Pierre, Phillips, Lara G., Patel, K.J., Balasubramanian, Shankar, Sale, Julian E.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2012
Subjects:
Gene Regulation, Chromatin and Epigenetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3287192/
https://ncbi.nlm.nih.gov/pubmed/22021381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr868
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