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FANCJ coordinates two pathways that maintain epigenetic stability at G-quadruplex DNA
We have previously reported that DT40 cells deficient in the Y-family polymerase REV1 are defective in replicating G-quadruplex DNA. In vivo this leads to uncoupling of DNA synthesis from redeposition of histones displaced ahead of the replication fork, which in turn leads to loss of transcriptional...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3287192/ https://ncbi.nlm.nih.gov/pubmed/22021381 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr868 |
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