Activation-induced cytidine deaminase localizes to G-quadruplex motifs at mutation hotspots in lymphoma

Diffuse large B-cell lymphoma (DLBCL) is a molecularly heterogeneous group of malignancies with frequent genetic abnormalities. G-quadruplex (G4) DNA structures may facilitate this genomic instability through association with activation-induced cytidine deaminase (AID), an antibody diversification e...

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Veröffentlicht in:NAR Cancer
Hauptverfasser: Xu, Ying-Zhi, Jenjaroenpun, Piroon, Wongsurawat, Thidathip, Byrum, Stephanie D, Shponka, Volodymyr, Tannahill, David, Chavez, Elizabeth A, Hung, Stacy S, Steidl, Christian, Balasubramanian, Shankar, Rimsza, Lisa M, Kendrick, Samantha
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2020
Schlagworte:
Cancer Gene Regulation, Chromatin, and Epigenetics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7556405/
https://ncbi.nlm.nih.gov/pubmed/33094287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/narcan/zcaa029
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