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Quantitative model of R-loop forming structures reveals a novel level of RNA–DNA interactome complexity

R-loop is the structure co-transcriptionally formed between nascent RNA transcript and DNA template, leaving the non-transcribed DNA strand unpaired. This structure can be involved in the hyper-mutation and dsDNA breaks in mammalian immunoglobulin (Ig) genes, oncogenes and neurodegenerative disease...

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Bibliografische gegevens
Hoofdauteurs: Wongsurawat, Thidathip, Jenjaroenpun, Piroon, Kwoh, Chee Keong, Kuznetsov, Vladimir
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2012
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3258121/
https://ncbi.nlm.nih.gov/pubmed/22121227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr1075
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