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Quantitative model of R-loop forming structures reveals a novel level of RNA–DNA interactome complexity
R-loop is the structure co-transcriptionally formed between nascent RNA transcript and DNA template, leaving the non-transcribed DNA strand unpaired. This structure can be involved in the hyper-mutation and dsDNA breaks in mammalian immunoglobulin (Ig) genes, oncogenes and neurodegenerative disease...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3258121/ https://ncbi.nlm.nih.gov/pubmed/22121227 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr1075 |
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