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Toward predictive R-loop computational biology: genome-scale prediction of R-loops reveals their association with complex promoter structures, G-quadruplexes and transcriptionally active enhancers

R-loops are three-stranded RNA:DNA hybrid structures essential for many normal and pathobiological processes. Previously, we generated a quantitative R-loop forming sequence (RLFS) model, quantitative model of R-loop-forming sequences (QmRLFS) and predicted ∼660 000 RLFSs; most of them located in ge...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Kuznetsov, Vladimir A, Bondarenko, Vladyslav, Wongsurawat, Thidathip, Yenamandra, Surya P, Jenjaroenpun, Piroon
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6125637/
https://ncbi.nlm.nih.gov/pubmed/29945198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky554
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