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N-terminal acetylation and replicative age affect proteasome localization and cell fitness during aging

Specific degradation of proteins is essential for virtually all cellular processes and is carried out predominantly by the proteasome. The proteasome is important for clearance of damaged cellular proteins. Damaged proteins accumulate over time and excess damaged proteins can aggregate and induce th...

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Detalhes bibliográficos
Publicado no:J Cell Sci
Main Authors: van Deventer, Sjoerd, Menendez-Benito, Victoria, van Leeuwen, Fred, Neefjes, Jacques
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4282048/
https://ncbi.nlm.nih.gov/pubmed/25413350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.157354
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