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N-Terminal Acetylation Affects α-Synuclein Fibril Polymorphism
Parkinson’s disease etiology involves amyloid formation by α-synuclein (αSyn). In vivo, αSyn is constitutively acetylated at the α-amino N-terminus. Here, we find N-terminally acetylated αSyn (Ac-αSyn) aggregates more slowly than non-acetylated αSyn (NH(3)-αSyn) with significantly reduced sensitivit...
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| Udgivet i: | Biochemistry |
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| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6721997/ https://ncbi.nlm.nih.gov/pubmed/31424918 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b00629 |
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