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Effects of phosphatidylcholine membrane fluidity on the conformation and aggregation of N-terminally acetylated α-synuclein

Membrane association of α-synuclein (α-syn), a neuronal protein associated with Parkinson's disease (PD), is involved in α-syn function and pathology. Most previous studies on α-syn–membrane interactions have not used the physiologically relevant N-terminally acetylated (N-acetyl) α-syn form no...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: O'Leary, Emma I., Jiang, Zhiping, Strub, Marie-Paule, Lee, Jennifer C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6052208/
https://ncbi.nlm.nih.gov/pubmed/29853639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002780
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