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Structural Insights into α-Synuclein Fibril Polymorphism: Effects of Parkinson’s Disease Related C-Terminal Truncations

Lewy bodies, hallmarks of Parkinson’s disease, contains C-terminally truncated (ΔC) α-synuclein (α-syn). Here, we report fibril structures of three N-terminally acetylated (Ac) α-syn constructs, Ac1–140, Acl–122, and Ac1–103, solved by cryoelectron microscopy. Both ΔC-α-syn variants exhibited faster...

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Bibliografiske detaljer
Udgivet i:J Mol Biol
Main Authors: Ni, Xiaodan, McGlinchey, Ryan P., Jiang, Jiansen, Lee, Jennifer C.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6733637/
https://ncbi.nlm.nih.gov/pubmed/31295458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2019.07.001
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