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Structural Insights into α-Synuclein Fibril Polymorphism: Effects of Parkinson’s Disease Related C-Terminal Truncations
Lewy bodies, hallmarks of Parkinson’s disease, contains C-terminally truncated (ΔC) α-synuclein (α-syn). Here, we report fibril structures of three N-terminally acetylated (Ac) α-syn constructs, Ac1–140, Acl–122, and Ac1–103, solved by cryoelectron microscopy. Both ΔC-α-syn variants exhibited faster...
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| Udgivet i: | J Mol Biol |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6733637/ https://ncbi.nlm.nih.gov/pubmed/31295458 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2019.07.001 |
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