CDK6 as a key regulator of hematopoietic and leukemic stem cell activation

The cyclin-dependent kinase 6 (CDK6) and CDK4 have redundant functions in regulating cell-cycle progression. We describe a novel role for CDK6 in hematopoietic and leukemic stem cells (hematopoietic stem cells [HSCs] and leukemic stem cells [LSCs]) that exceeds its function as a cell-cycle regulator...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Scheicher, Ruth, Hoelbl-Kovacic, Andrea, Bellutti, Florian, Tigan, Anca-Sarmiza, Prchal-Murphy, Michaela, Heller, Gerwin, Schneckenleithner, Christine, Salazar-Roa, María, Zöchbauer-Müller, Sabine, Zuber, Johannes, Malumbres, Marcos, Kollmann, Karoline, Sexl, Veronika
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2015
Assuntos:
Hematopoiesis and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4281832/
https://ncbi.nlm.nih.gov/pubmed/25342715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-06-584417
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