A robust approach for the generation of functional hematopoietic progenitor cell lines to model leukemic transformation

Studies of molecular mechanisms of hematopoiesis and leukemogenesis are hampered by the unavailability of progenitor cell lines that accurately mimic the situation in vivo. We now report a robust method to generate and maintain LSK (Lin(−), Sca-1(+), c-Kit(+)) cells, which closely resemble MPP1 cell...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Doma, Eszter, Mayer, Isabella Maria, Brandstoetter, Tania, Maurer, Barbara, Grausenburger, Reinhard, Menzl, Ingeborg, Zojer, Markus, Hoelbl-Kovacic, Andrea, Carlsson, Leif, Heller, Gerwin, Kollmann, Karoline, Sexl, Veronika
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2020
Assuntos:
Hematopoiesis and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7805318/
https://ncbi.nlm.nih.gov/pubmed/33570624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020003022
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