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c-JUN prevents methylation of p16INK4a (and Cdk6): the villain turned bodyguard

A novel way by which the AP-1 factor c-JUN interferes with tumorigenesis has recently been elucidated [1]. In a model of murine leukemia, c-JUN prevents the epigenetic silencing of the cell cycle kinase CDK6. In the absence of c-JUN, CDK6 is down-regulated and the 5'region of the gene is methyl...

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Autors principals: Kollmann, Karoline, Heller, Gerwin, Sexl, Veronika
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2011
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248190/
https://ncbi.nlm.nih.gov/pubmed/21789792
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