CDK6 antagonizes p53-induced responses during tumorigenesis

Tumor formation is a multi-step process during which cells acquire genetic and epigenetic changes until they reach a fully transformed state. We show that CDK6 contributes to tumor formation by regulating transcriptional responses in a stage-specific manner. In early stages CDK6 kinase induces a com...

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Bibliografiske detaljer
Udgivet i:Cancer Discov
Main Authors: Bellutti, Florian, Tigan, Anca-Sarmiza, Nebenfuehr, Sofie, Dolezal, Marlies, Zojer, Markus, Grausenburger, Reinhard, Hartenberger, Svenja, Kollmann, Sebastian, Doma, Eszter, Prchal-Murphy, Michaela, Uras, Iris Z., Höllein, Alexander, Neuberg, Donna S., Ebert, Benjamin L., Ringler, Anna, Mueller, Andre C., Loizou, Joanna I., Hinds, Philip W., Vogl, Claus, Heller, Gerwin, Kubicek, Stefan, Zuber, Johannes, Malumbres, Marcos, Farlik, Matthias, Villunger, Andreas, Kollmann, Karoline, Sexl, Veronika
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6031305/
https://ncbi.nlm.nih.gov/pubmed/29899063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-17-0912
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