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The Q510E mutation in Shp2 perturbs heart valve development by increasing cell migration
Tightly regulated cellular signaling is critical for correct heart valve development, but how and why signaling is dysregulated in congenital heart disease is not very well known. We focused on protein tyrosine phosphatase Shp2, because mutations in this signaling modulator frequently cause valve ma...
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| Pubblicato in: | J Appl Physiol (1985) |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Physiological Society
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4281644/ https://ncbi.nlm.nih.gov/pubmed/25359717 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/japplphysiol.00008.2014 |
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