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The Noonan Syndrome Mutation Q79R in Shp2 Increases Proliferation of Valve Primordia Mesenchymal Cells via ERK1/2 signaling
The molecular pathways regulating valve development are only partially understood. Recent studies indicate that dysregulation of MAPK signaling might play a major role in the pathogenesis of congenital valvular malformations and, in this study, we explore the role of ERK1/2 activation in valve primo...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1388074/ https://ncbi.nlm.nih.gov/pubmed/16166557 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/01.RES.0000186194.06514.b0 |
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