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Role of ERK1/2 signaling in congenital valve malformations in Noonan syndrome
Noonan syndrome (NS) is the most common nonchromosomal genetic disorder associated with cardiovascular malformations. The most prominent cardiac defects in NS are pulmonary valve stenosis and hypertrophic cardiomyopathy. Gain-of-function mutations in the protein tyrosine phosphatase Shp2 have been i...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2596231/ https://ncbi.nlm.nih.gov/pubmed/19017799 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0806556105 |
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