טוען...
Design of Chemically Stable, Potent, and Efficacious MDM2 Inhibitors That Exploit the Retro-Mannich Ring-Opening-Cyclization Reaction Mechanism in Spiro-oxindoles
[Image: see text] Inhibition of the MDM2–p53 protein–protein interaction is being actively pursued as a new anticancer therapeutic strategy, and spiro-oxindoles have been designed as a class of potent and efficacious small-molecule inhibitors of this interaction (MDM2 inhibitors). Our previous study...
שמור ב:
| הוצא לאור ב: | J Med Chem |
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| Main Authors: | , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
American Chemical
Society
2014
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| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4281096/ https://ncbi.nlm.nih.gov/pubmed/25496041 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm501541j |
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