Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics

BACKGROUND AND PURPOSE: Clinical use of cinacalcet in hyperparathyroidism is complicated by its tendency to induce hypocalcaemia, arising partly from activation of calcium-sensing receptors (CaS receptors) in the thyroid and stimulation of calcitonin release. CaS receptor allosteric modulators that...

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Publicat a:Br J Pharmacol
Autors principals: Cook, A E, Mistry, S N, Gregory, K J, Furness, S G B, Sexton, P M, Scammells, P J, Conigrave, A D, Christopoulos, A, Leach, K
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Publishing Ltd 2015
Matèries:
Research Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4280977/
https://ncbi.nlm.nih.gov/pubmed/25220431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12937
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