Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma

Osteosarcoma is the most common primary bone tumor, yet there have been no substantial advances in treatment or survival in three decades. We examined 59 tumor/normal pairs by whole-exome, whole-genome, and RNA-sequencing. Only the TP53 gene was mutated at significant frequency across all samples. T...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Perry, Jennifer A., Kiezun, Adam, Tonzi, Peter, Van Allen, Eliezer M., Carter, Scott L., Baca, Sylvan C., Cowley, Glenn S., Bhatt, Ami S., Rheinbay, Esther, Pedamallu, Chandra Sekhar, Helman, Elena, Taylor-Weiner, Amaro, McKenna, Aaron, DeLuca, David S., Lawrence, Michael S., Ambrogio, Lauren, Sougnez, Carrie, Sivachenko, Andrey, Walensky, Loren D., Wagle, Nikhil, Mora, Jaume, de Torres, Carmen, Lavarino, Cinzia, Dos Santos Aguiar, Simone, Yunes, Jose Andres, Brandalise, Silvia Regina, Mercado-Celis, Gabriela Elisa, Melendez-Zajgla, Jorge, Cárdenas-Cardós, Rocío, Velasco-Hidalgo, Liliana, Roberts, Charles W. M., Garraway, Levi A., Rodriguez-Galindo, Carlos, Gabriel, Stacey B., Lander, Eric S., Golub, Todd R., Orkin, Stuart H., Getz, Gad, Janeway, Katherine A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4280630/
https://ncbi.nlm.nih.gov/pubmed/25512523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1419260111
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