Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma

Osteosarcoma is the most common primary bone tumor, yet there have been no substantial advances in treatment or survival in three decades. We examined 59 tumor/normal pairs by whole-exome, whole-genome, and RNA-sequencing. Only the TP53 gene was mutated at significant frequency across all samples. T...

全面介紹

Na minha lista:
書目詳細資料
發表在:Proc Natl Acad Sci U S A
Main Authors: Perry, Jennifer A., Kiezun, Adam, Tonzi, Peter, Van Allen, Eliezer M., Carter, Scott L., Baca, Sylvan C., Cowley, Glenn S., Bhatt, Ami S., Rheinbay, Esther, Pedamallu, Chandra Sekhar, Helman, Elena, Taylor-Weiner, Amaro, McKenna, Aaron, DeLuca, David S., Lawrence, Michael S., Ambrogio, Lauren, Sougnez, Carrie, Sivachenko, Andrey, Walensky, Loren D., Wagle, Nikhil, Mora, Jaume, de Torres, Carmen, Lavarino, Cinzia, Dos Santos Aguiar, Simone, Yunes, Jose Andres, Brandalise, Silvia Regina, Mercado-Celis, Gabriela Elisa, Melendez-Zajgla, Jorge, Cárdenas-Cardós, Rocío, Velasco-Hidalgo, Liliana, Roberts, Charles W. M., Garraway, Levi A., Rodriguez-Galindo, Carlos, Gabriel, Stacey B., Lander, Eric S., Golub, Todd R., Orkin, Stuart H., Getz, Gad, Janeway, Katherine A.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2014
主題:
PNAS Plus
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4280630/
https://ncbi.nlm.nih.gov/pubmed/25512523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1419260111
標簽: 添加標簽
沒有標簽, 成為第一個標記此記錄!

相似書籍