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mTORC2 modulates feedback regulation of p38 MAPK activity via DUSP10/MKP5 to confer differential responses to PP242 in glioblastoma

Dual-specificity phosphatases (DUSPs) dephosphorylate MAP kinases (MAPKs) resulting in their inactivation. Activation of MAPK signaling leads to enhanced DUSP expression, thus establishing feedback regulation of the MAPK pathway. The DUSPs are subject to regulation at the post-translational level vi...

詳細記述

保存先:
書誌詳細
出版年:Genes Cancer
主要な著者: Benavides-Serrato, Angelica, Anderson, Lauren, Holmes, Brent, Cloninger, Cheri, Artinian, Nicholas, Bashir, Tariq, Gera, Joseph
フォーマット: Artigo
言語:Inglês
出版事項: Impact Journals LLC 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4279437/
https://ncbi.nlm.nih.gov/pubmed/25568665
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