The Mitochondrial Complex V–Associated Large-Conductance Inner Membrane Current Is Regulated by Cyclosporine and Dexpramipexole

Inefficiency of oxidative phosphorylation can result from futile leak conductance through the inner mitochondrial membrane. Stress or injury may exacerbate this leak conductance, putting cells, and particularly neurons, at risk of dysfunction and even death when energy demand exceeds cellular energy...

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Publié dans:Mol Pharmacol
Auteurs principaux: Alavian, Kambiz N., Dworetzky, Steven I., Bonanni, Laura, Zhang, Ping, Sacchetti, Silvio, Li, Hongmei, Signore, Armando P., Smith, Peter J. S., Gribkoff, Valentin K., Jonas, Elizabeth A.
Format: Artigo
Langue:Inglês
Publié: The American Society for Pharmacology and Experimental Therapeutics 2015
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4279080/
https://ncbi.nlm.nih.gov/pubmed/25332381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.114.095661
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