The Mitochondrial Complex V–Associated Large-Conductance Inner Membrane Current Is Regulated by Cyclosporine and Dexpramipexole

Inefficiency of oxidative phosphorylation can result from futile leak conductance through the inner mitochondrial membrane. Stress or injury may exacerbate this leak conductance, putting cells, and particularly neurons, at risk of dysfunction and even death when energy demand exceeds cellular energy...

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Publicado en:Mol Pharmacol
Autores principales: Alavian, Kambiz N., Dworetzky, Steven I., Bonanni, Laura, Zhang, Ping, Sacchetti, Silvio, Li, Hongmei, Signore, Armando P., Smith, Peter J. S., Gribkoff, Valentin K., Jonas, Elizabeth A.
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2015
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4279080/
https://ncbi.nlm.nih.gov/pubmed/25332381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.114.095661
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