Chitosan/siRNA Nanoparticles Targeting Cyclooxygenase Type 2 Attenuate Unilateral Ureteral Obstruction-induced Kidney Injury in Mice

Cyclooxygenase type 2 (COX-2) plays a predominant role in the progression of kidney injury in obstructive nephropathy. The aim of this study was to test the efficacy of chitosan/small interfering RNA (siRNA) nanoparticles to knockdown COX-2 specifically in macrophages to prevent kidney injury induce...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Theranostics
Main Authors: Yang, Chuanxu, Nilsson, Line, Cheema, Muhammad Umar, Wang, Yan, Frøkiær, Jørgen, Gao, Shan, Kjems, Jørgen, Nørregaard, Rikke
Format: Artigo
Jezik:Inglês
Izdano: Ivyspring International Publisher 2015
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4278998/
https://ncbi.nlm.nih.gov/pubmed/25553102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.9717
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