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Disruption of cyclooxygenase type 2 exacerbates apoptosis and renal damage during obstructive nephropathy

Renal oxidative stress is increased in response to ureteral obstruction. In vitro, cyclooxygenase (COX)-2 activity contributes to protection against oxidants. In the present study, we tested the hypothesis that COX-2 activity counters oxidative stress and apoptosis in an in vivo model of obstructive...

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Bibliografski detalji
Izdano u:Am J Physiol Renal Physiol
Glavni autori: Nilsson, Line, Madsen, Kirsten, Krag, Søren, Frøkiær, Jørgen, Jensen, Boye L., Nørregaard, Rikke
Format: Artigo
Jezik:Inglês
Izdano: American Physiological Society 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4683307/
https://ncbi.nlm.nih.gov/pubmed/26671967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00253.2015
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