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Disruption of cyclooxygenase type 2 exacerbates apoptosis and renal damage during obstructive nephropathy
Renal oxidative stress is increased in response to ureteral obstruction. In vitro, cyclooxygenase (COX)-2 activity contributes to protection against oxidants. In the present study, we tested the hypothesis that COX-2 activity counters oxidative stress and apoptosis in an in vivo model of obstructive...
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| Publié dans: | Am J Physiol Renal Physiol |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Physiological Society
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4683307/ https://ncbi.nlm.nih.gov/pubmed/26671967 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00253.2015 |
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