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Crystallographic analysis of TPP riboswitch binding by small molecule ligands discovered through fragment-based drug discovery approaches
Riboswitches are structured mRNA elements that regulate gene expression in response to metabolite or second messenger binding, and are promising targets for drug discovery. Fragment-based drug discovery methods have identified weakly binding small molecule “fragments” that bind a thiamine pyrophosph...
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| Publicado no: | Methods Enzymol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4274939/ https://ncbi.nlm.nih.gov/pubmed/25432751 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/B978-0-12-801122-5.00010-6 |
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